PMID: 42301783

The ERAD pathway mediates cross talk between two control points in cholesterol synthesis: HMG CoA reductase and squalene monooxygenase.

Faulkner Rebecca A, Jo Youngah, Garland-Brasher Kristina, DeBose-Boyd Russell A

Proceedings of the National Academy of Sciences of the United States of America · 2026

Vol. 123, Issue 25, pp. e2602559123

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Hydroxymethylglutaryl CoA ReductasesCholesterolSqualene MonooxygenaseEndoplasmic Reticulum-Associated DegradationMembrane ProteinsHumansUbiquitin-Protein LigasesEndoplasmic ReticulumIntracellular Signaling Peptides and ProteinsAnimals

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