PMID: 41734593

Structure-activity relationship profiling of N-substituted 8-trifluoromethyl-9H-purin-6-amines as mitochondrial protonophores.

Krinos Emily L, Fields Rei J, DeLuca Isabella M, Foutz Mary A, Li Catherine, Hargett Stefan R, Beretta Martina, Zhou Mingyan, Shrestha Riya, Gwinn Reilly K

European journal of medicinal chemistry · 2026

Vol. 308, pp. 118694

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Structure-Activity RelationshipAnimalsMitochondriaRatsMiceMolecular StructureProton IonophoresAminesDose-Response Relationship, DrugMale

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